Generic Top-Level Domains (gTLDs) are general, widely-used domain extensions like .com, .net, or .org that are not tied to any specific country or territory. On the other hand, Country Code Top-Level Domains (ccTLDs) are uniquely assigned to individual countries or territories, such as .uk for the United Kingdom or .ca for Canada. These ccTLDs help signify the geographic location or target audience of a website.